Handbook of Cannabis and Related Pathologies:Biology, Pharmacology, Diagnosis, and Treatment
Handbook of Cannabis and Related Pathologies: Biology, Pharmacology, Diagnosis, and Treatment is the first book to take an interdisciplinary approach to the understanding of cannabis use and misuse. Recent worldwide trends toward decriminalizing marijuana for medical use have increased legal use of the drug and recreational use remains high, making cannabis one of the most commonly used drugs. Cannabis has a wide range of adverse neurological effects, and use and abuse can lead to physical, social, and psychopathological issues that are multifarious and complex. Effective understanding and treatment requires knowledge of the drugs effects from across scientific disciplines. This book provides an overview of the biological and pharmacological components of the cannabis plant, outlines its neurological, social, and psychopathological effects, assists in the diagnosis and screening for use and dependency, and aids researchers in developing effective treatments for cannabis-related issues and disorders. Fully illustrated, with contributions from internationally recognized experts, it is the go-to resource for neuroscientists, pharmacologists, pathologists, public-health workers, and any other researcher who needs an in-depth and cross-disciplinary understanding of cannabis and its effects. Comprehensive chapters include an abstract, key facts, mini dictionary of terms, and summary points Presents illustrations with at least six figures, tables, and diagrams per chapter Provides a one-stop-shopping synopsis of everything to do with cannabis and its related pathology, from chemicals and cells, individuals and communities, and diagnosis and treatment Offers an integrated and informed synopsis of the complex issues surrounding cannabis as a substance, its use, and its misuse
Cet ouvrage inédit, seconde édition française enrichie et réactualisée du fameux titre allemand Hanf als Medizin, est le premier guide pratique traitant exclusivement des applications médicales du cannabis (ou chanvre) et de ses produits dérivés, aussi bien naturels que synthétiques. Écrit par lun des plus grands spécialistes internationaux du cannabis thérapeutique, le docteur en médecine Franjo Grotenhermen, il réunit, dans un style clair et concis, une quantité importante dinformations sur les nouveaux traitements possibles et reconnus à base de cannabis médicinal, de Dronabinol (THC) ou de Cannabidiol (CBD), les principales substances actives du cannabis. Plus de 350 références choisies parmi la vaste littérature scientifique sont citées, et il décrit la riche histoire de lusage médical du cannabis à travers les ?ges. Ce livre pose les bases des connaissances actuelles sur le système cannabino?de endogène. Les différents domaines dapplication, incluant une quarantaine de pathologies, ainsi que les risques, les effets secondaires, les posologies, les modes dabsorption et les interactions éventuelles avec dautres médicaments sont présentés et détaillés intégralement. Louvrage contient également de nombreux conseils et de précieuses recommandations issus de la longue expérience clinique de lauteur.
The science of cannabinoids is 50 years old. These past years provided a remarkable and constant number of breakthroughs, showing that the signaling mediated by endocannabinoids and lipid mediators impacts almost every function of the body. Indeed, this represents a special field of research, which allows tackling the complexity of biological functions, and provides potential therapeutic frameworks for a plethora of diseases. The number of exciting discoveries brought up to the scientific community almost on a daily basis highlights the importance of an updated volume on this topic. Particularly, given that potential therapeutic benefits of cannabis and cannabinoids are currently under heavy analysis in many Countries worldwide. Hence, the main objective of this book is to explore not only some of the many functions of endocannabinoids (and lipid mediators) in physiological control of networks at a cellular and molecular level, but also to extend this knowledge for potential use of cannabinoids and/or drugs regulating endocannabinoid levels in vivo as therapeutic target(s) in neurological and neuropsychiatric disorders. In this book new findings and ideas about the endocannabinoid system and its roles as neuronal circuit modulator related to human brain pathologies characterized by alterations in neuroplasticity will be highlighted. Endocannabinoid roles in key systems controlling appetite, pain, learning and memory, as well as sleep and stress responses will be presented. In addition, pathological processes associated with changes in endocannabinoid signaling will be discussed in the context of anxiety, autism, depression and addiction. This book will provide an excellent background to researchers looking for extending their areas of interest, and to newcomers in the field. Miriam Melis is an Associate Professor at the University of Cagliari, Italy. She holds a PharmD in Pharmacy (University of Palermo, 1993) as well as a PhD in Neuroscience University of Cagliari, 2011). During her career Miriam Melis worked as a Research Fellow for two years at the Ernest Gallo Clinic and Research Center, San Francisco, CA, US and as a Visiting Scientist at Lund Universitet Wallenberg Neuroscience Center in 2011. Her current research is focused on understanding neurobiological underpinnings (e.g., adaptations of both mesocorticolimbic dopamine pathway and endocannabinoid system) of resilience and susceptibility to neuropsychiatric disorders (e.g., substance use disorder, antisocial behavior, anxiety, depression). Her group discovered that dopamine neurons can synthesize and release lipid signaling molecules (i.e. endocannabinoids and their cognate molecules) under both physiological and pathological conditions. She has published 34 research papers as well as 2 book chapters on this topic.